{"$schema":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/api/public/schemas/claims.schema.json","generated_at":"2026-06-11T13:52:43.292Z","page":1,"page_size":100,"total":3863,"total_pages":39,"filters":{"verdict":null,"vertical":null,"claim_type":null,"updated_since":null,"q":null},"claims":[{"id":"ptd-270001-300002","claim_id":300002,"document_id":270001,"document_title":"Salmon-Derived Biotech Product Feasibility Analysis","vertical_domain":"salmon_biotech","claim_text":"Fish are explicitly exempt from transmissible spongiform encephalopathy (TSE) regulations under EU Regulation 722/2012 and FDA guidance because they are not TSE-susceptible species","claim_type":"general_molecular","extracted_value":"Fish are not TSE-susceptible species","pdb_id":null,"verdict":"Supported","verdict_rationale":"EU Commission Regulation No 722/2012 Article 1(2) explicitly limits TSE requirements to bovine, ovine, caprine species, deer, elk, mink and cats. Fish including Atlantic salmon are not listed and are therefore explicitly exempt. Source: CELEX:32012R0722.","confidence_score":0.95,"verdict_method":"override","evidence_url":"https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=CELEX:32012R0722","page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300002","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270001#claim-300002","created_at":"2026-06-10T09:26:47.000Z","updated_at":"2026-06-10T10:36:13.000Z"},{"id":"ptd-270006-300043","claim_id":300043,"document_id":270006,"document_title":"Circular Approach to Biomanufacturing: Enhancing Therapeutic Protein Production Using Chum Salmon Head Peptone.","vertical_domain":"salmon_biotech","claim_text":"human growth hormone (hGH) in Escherichia coli BL21(DE3)","claim_type":"organism","extracted_value":"Escherichia coli BL21(DE3)","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Escherichia coli BL21(DE3)' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300043","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270006#claim-300043","created_at":"2026-06-10T09:52:06.000Z","updated_at":"2026-06-10T09:52:14.000Z"},{"id":"ptd-270006-300037","claim_id":300037,"document_id":270006,"document_title":"Circular Approach to Biomanufacturing: Enhancing Therapeutic Protein Production Using Chum Salmon Head Peptone.","vertical_domain":"salmon_biotech","claim_text":"chum salmon (Oncorhynchus keta)","claim_type":"organism","extracted_value":"Oncorhynchus keta","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Oncorhynchus keta' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300037","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270006#claim-300037","created_at":"2026-06-10T09:52:06.000Z","updated_at":"2026-06-10T09:52:13.000Z"},{"id":"ptd-270006-300042","claim_id":300042,"document_id":270006,"document_title":"Circular Approach to Biomanufacturing: Enhancing Therapeutic Protein Production Using Chum Salmon Head Peptone.","vertical_domain":"salmon_biotech","claim_text":"human growth hormone (hGH) in Escherichia coli BL21(DE3)","claim_type":"protein_name","extracted_value":"human growth hormone (hGH)","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'human growth hormone (hGH)' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300042","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270006#claim-300042","created_at":"2026-06-10T09:52:06.000Z","updated_at":"2026-06-10T09:52:12.000Z"},{"id":"ptd-270006-300039","claim_id":300039,"document_id":270006,"document_title":"Circular Approach to Biomanufacturing: Enhancing Therapeutic Protein Production Using Chum Salmon Head Peptone.","vertical_domain":"salmon_biotech","claim_text":"The resulting chum salmon head peptone (CSHP) exhibited favorable characteristics, including a low average molecular mass (557 Da)","claim_type":"general_molecular","extracted_value":"average molecular mass (557 Da)","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'average molecular mass (557 Da)' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300039","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270006#claim-300039","created_at":"2026-06-10T09:52:06.000Z","updated_at":"2026-06-10T09:52:12.000Z"},{"id":"ptd-270006-300038","claim_id":300038,"document_id":270006,"document_title":"Circular Approach to Biomanufacturing: Enhancing Therapeutic Protein Production Using Chum Salmon Head Peptone.","vertical_domain":"salmon_biotech","claim_text":"Protamex achieved the highest hydrolysis and recovery rates.","claim_type":"protein_name","extracted_value":"Protamex","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Protamex' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300038","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270006#claim-300038","created_at":"2026-06-10T09:52:06.000Z","updated_at":"2026-06-10T09:52:12.000Z"},{"id":"ptd-270006-300041","claim_id":300041,"document_id":270006,"document_title":"Circular Approach to Biomanufacturing: Enhancing Therapeutic Protein Production Using Chum Salmon Head Peptone.","vertical_domain":"salmon_biotech","claim_text":"CSHP was evaluated as a nitrogen source for recombinant protein production and supported higher expression of human superoxide dismutase (hSOD)","claim_type":"protein_name","extracted_value":"human superoxide dismutase (hSOD)","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'human superoxide dismutase (hSOD)' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300041","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270006#claim-300041","created_at":"2026-06-10T09:52:06.000Z","updated_at":"2026-06-10T09:52:11.000Z"},{"id":"ptd-270006-300040","claim_id":300040,"document_id":270006,"document_title":"Circular Approach to Biomanufacturing: Enhancing Therapeutic Protein Production Using Chum Salmon Head Peptone.","vertical_domain":"salmon_biotech","claim_text":"a high amino nitrogen content (4.9%)","claim_type":"general_molecular","extracted_value":"amino nitrogen content (4.9%)","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'amino nitrogen content (4.9%)' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300040","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270006#claim-300040","created_at":"2026-06-10T09:52:06.000Z","updated_at":"2026-06-10T09:52:11.000Z"},{"id":"ptd-270005-300035","claim_id":300035,"document_id":270005,"document_title":"Hyaluronic acid production by Streptococcus zooepidemicus in marine by-products media from mussel processing wastewaters and tuna peptone viscera.","vertical_domain":"salmon_biotech","claim_text":"Mussel processing wastewater (MPW) was used as a sugar source and tuna peptone (TP) from viscera residue as a protein substrate for the production of hyaluronic acid (HA), biomass and lactic acid (LA) by Streptococcus zooepidemicus in batch fermentation.","claim_type":"organism","extracted_value":"Streptococcus zooepidemicus","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Streptococcus zooepidemicus' not found in PubChem; [adapter] Manual review recommended [Audit note: The model's output should include both the 'Verdict' and 'Rationale' fields as presented in the optimized prompt. For example, it should output: {\"Verdict\": \"Insufficient Evidence\", \"Rationale\": \"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Streptococcus zooepidemicus' not found in PubChem; [adapter] Manual review recommended\"}]","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300035","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270005#claim-300035","created_at":"2026-06-10T09:51:51.000Z","updated_at":"2026-06-10T09:51:59.000Z"},{"id":"ptd-270005-300036","claim_id":300036,"document_id":270005,"document_title":"Hyaluronic acid production by Streptococcus zooepidemicus in marine by-products media from mussel processing wastewaters and tuna peptone viscera.","vertical_domain":"salmon_biotech","claim_text":"Complete residual media achieved high production (3.67, 2.46 and 30.83 g l(-1) of biomass, HA and LA respectively) and a high molecular weight of HA (approximately 2500 kDa).","claim_type":"general_molecular","extracted_value":"high molecular weight of HA (approximately 2500 kDa)","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'high molecular weight of HA (approximately 2500 kDa)' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300036","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270005#claim-300036","created_at":"2026-06-10T09:51:51.000Z","updated_at":"2026-06-10T09:51:57.000Z"},{"id":"ptd-270004-300034","claim_id":300034,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"These peptones were included (in the range of 2.6-11 g/L of soluble protein) as main source of organic nitrogen (protein substrates) in low-cost media for the culture of lactic acid bacteria (LAB), marine probiotic bacteria (MPB) and ubiquitous Gram+ bacteria.","claim_type":"organism","extracted_value":"Gram+ bacteria","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Gram+ bacteria' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300034","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300034","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:48.000Z"},{"id":"ptd-270004-300033","claim_id":300033,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"These peptones were included (in the range of 2.6-11 g/L of soluble protein) as main source of organic nitrogen (protein substrates) in low-cost media for the culture of lactic acid bacteria (LAB), marine probiotic bacteria (MPB) and ubiquitous Gram+ bacteria.","claim_type":"organism","extracted_value":"marine probiotic bacteria (MPB)","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'marine probiotic bacteria (MPB)' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300033","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300033","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:47.000Z"},{"id":"ptd-270004-300032","claim_id":300032,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"These peptones were included (in the range of 2.6-11 g/L of soluble protein) as main source of organic nitrogen (protein substrates) in low-cost media for the culture of lactic acid bacteria (LAB), marine probiotic bacteria (MPB) and ubiquitous Gram+ bacteria.","claim_type":"organism","extracted_value":"lactic acid bacteria (LAB)","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'lactic acid bacteria (LAB)' not found in PubChem; [adapter] Manual review recommended [Audit note: The model must include the verdict in its output, consistent with the provided rationale. For example, it should output 'Verdict: Insufficient Evidence' followed by the rationale.]","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300032","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300032","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:47.000Z"},{"id":"ptd-270004-300031","claim_id":300031,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"These peptones were included (in the range of 2.6-11 g/L of soluble protein) as main source of organic nitrogen (protein substrates) in low-cost media for the culture of lactic acid bacteria (LAB), marine probiotic bacteria (MPB) and ubiquitous Gram+ bacteria.","claim_type":"general_molecular","extracted_value":"peptones used as main source of organic nitrogen (protein substrates) for culture of lactic acid bacteria (LAB), marine probiotic bacteria (MPB) and ubiquitous Gram+ bacteria","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'peptones used as main source of organic nitrogen (protein substrates) for culture of lactic acid bacteria (LAB), marine probiotic bacteria (MPB) and ubiquitous Gram+ bacteria' not found in PubChem; [adapter] Manual review recommended [Audit note: The model should explicitly state the verdict, for example: 'Verdict: Insufficient Evidence. Rationale: Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'peptones used as main source of organic nitrogen (protein substrates) for culture of lactic acid bacteria (LAB), marine probiotic bacteria (MPB) and ubiquitous Gram+ bacteria' not found in PubChem; [adapter] Manual review recommended']","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300031","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300031","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:47.000Z"},{"id":"ptd-270004-300030","claim_id":300030,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"wastes generated from the industrial processing of turbot, salmon, trout, seabream and seabass.","claim_type":"organism","extracted_value":"seabass","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'seabass' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300030","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300030","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:47.000Z"},{"id":"ptd-270004-300029","claim_id":300029,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"wastes generated from the industrial processing of turbot, salmon, trout, seabream and seabass.","claim_type":"organism","extracted_value":"seabream","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'seabream' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300029","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300029","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:41.000Z"},{"id":"ptd-270004-300024","claim_id":300024,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"thermal processing (105 °C, 60 min)","claim_type":"experimental_method","extracted_value":"thermal processing","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'thermal processing' not found in PubChem; [adapter] Manual review recommended [Audit note: The model should include the 'Verdict' as specified in the optimized prompt, in addition to the 'Rationale'. For example, it should output: \"Verdict: Insufficient Evidence. Rationale: Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'thermal processing' not found in PubChem; [adapter] Manual review recommended\"]","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300024","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300024","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:41.000Z"},{"id":"ptd-270004-300023","claim_id":300023,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"Alcalase hydrolysis (0.1-0.2% v/w, 56-64 °C, pH 8.27-8.98, 3 h)","claim_type":"protein_name","extracted_value":"Alcalase","pdb_id":null,"verdict":"Supported","verdict_rationale":"Source: CID:3086051 (confidence 85%). [Audit note: The model needs to output the 'Verdict' as well as the 'Rationale'. The prompt should explicitly state the required output format, e.g., 'Verdict: [Verdict] Rationale: [Rationale]' to ensure all components are included.]","confidence_score":null,"verdict_method":"confidence_threshold","evidence_url":"https://pubchem.ncbi.nlm.nih.gov/compound/3086051","page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300023","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300023","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:41.000Z"},{"id":"ptd-270004-300028","claim_id":300028,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"wastes generated from the industrial processing of turbot, salmon, trout, seabream and seabass.","claim_type":"organism","extracted_value":"trout","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'trout' not found in PubChem; [adapter] Manual review recommended [Audit note: The model should be instructed to explicitly include the 'Verdict' field as provided in the optimized prompt, in addition to the 'Rationale'. For example, if the prompt provides 'Verdict: Insufficient Evidence', the model's output should start with 'Verdict: Insufficient Evidence' followed by the rationale.]","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300028","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300028","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:40.000Z"},{"id":"ptd-270004-300027","claim_id":300027,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"wastes generated from the industrial processing of turbot, salmon, trout, seabream and seabass.","claim_type":"organism","extracted_value":"salmon","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'salmon' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300027","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300027","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:40.000Z"},{"id":"ptd-270004-300025","claim_id":300025,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"peptones are produced from the Alcalase hydrolysis (0.1-0.2% v/w, 56-64 °C, pH 8.27-8.98, 3 h) and thermal processing (105 °C, 60 min) of wastes generated from the industrial processing of turbot, salmon, trout, seabream and seabass.","claim_type":"general_molecular","extracted_value":"peptones produced from Alcalase hydrolysis and thermal processing of turbot, salmon, trout, seabream and seabass wastes","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'peptones produced from Alcalase hydrolysis and thermal processing of turbot, salmon, trout, seabream and seabass wastes' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300025","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300025","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:39.000Z"},{"id":"ptd-270004-300022","claim_id":300022,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"Alcalase hydrolysis (0.1-0.2% v/w, 56-64 °C, pH 8.27-8.98, 3 h)","claim_type":"experimental_method","extracted_value":"Alcalase hydrolysis","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Alcalase hydrolysis' not found in PubChem; [adapter] Manual review recommended [Audit note: The model should include the 'Verdict' field as provided in the optimized prompt. For example, it should output: 'Verdict: Insufficient Evidence. Rationale: Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Alcalase hydrolysis' not found in PubChem; [adapter] Manual review recommended']","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300022","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300022","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:39.000Z"},{"id":"ptd-270004-300026","claim_id":300026,"document_id":270004,"document_title":"Biotechnological Valorization of Food Marine Wastes: Microbial Productions on Peptones Obtained from Aquaculture By-Products.","vertical_domain":"salmon_biotech","claim_text":"wastes generated from the industrial processing of turbot, salmon, trout, seabream and seabass.","claim_type":"organism","extracted_value":"turbot","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'turbot' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300026","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270004#claim-300026","created_at":"2026-06-10T09:51:33.000Z","updated_at":"2026-06-10T09:51:38.000Z"},{"id":"ptd-270003-300021","claim_id":300021,"document_id":270003,"document_title":"Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates.","vertical_domain":"salmon_biotech","claim_text":"We suggest an enzymatic solution for converting trimethylamine to the odorless trimethylamine N-oxide as a novel strategy to improve the smell quality of marine protein hydrolysates.","claim_type":"general_molecular","extracted_value":"Enzymatic conversion of trimethylamine to trimethylamine N-oxide","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Enzymatic conversion of trimethylamine to trimethylamine N-oxide' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300021","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270003#claim-300021","created_at":"2026-06-10T09:51:03.000Z","updated_at":"2026-06-10T09:51:19.000Z"},{"id":"ptd-270003-300013","claim_id":300013,"document_id":270003,"document_title":"Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates.","vertical_domain":"salmon_biotech","claim_text":"Trimethylamine (TMA) is a known contributor to malodor in fish.","claim_type":"general_molecular","extracted_value":"Trimethylamine (TMA) is a known contributor to malodor in fish","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Trimethylamine (TMA) is a known contributor to malodor in fish' not found in PubChem; [adapter] Manual review recommended [Audit note: Ensure the model output includes both the 'Verdict:' line and the 'Rationale:' line as specified in the optimized prompt. The model should output: 'Verdict: Insufficient Evidence Rationale: Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Trimethylamine (TMA) is a known contributor to malodor in fish' not found in PubChem; [adapter] Manual review recommended']","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300013","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270003#claim-300013","created_at":"2026-06-10T09:51:03.000Z","updated_at":"2026-06-10T09:51:12.000Z"},{"id":"ptd-270003-300019","claim_id":300019,"document_id":270003,"document_title":"Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates.","vertical_domain":"salmon_biotech","claim_text":"The enzymes were all active from pH 6.0 to 8.5, with functional stability being lowest around the optimal pH.","claim_type":"general_molecular","extracted_value":"Enzymes active from pH 6.0 to 8.5","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Enzymes active from pH 6.0 to 8.5' not found in PubChem; [adapter] Manual review recommended [Audit note: The model must include the 'Verdict' field in its output, consistent with the optimized prompt's structure. For example, 'Verdict: Insufficient Evidence'.]","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300019","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270003#claim-300019","created_at":"2026-06-10T09:51:03.000Z","updated_at":"2026-06-10T09:51:11.000Z"},{"id":"ptd-270003-300017","claim_id":300017,"document_id":270003,"document_title":"Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates.","vertical_domain":"salmon_biotech","claim_text":"From the 45 bacterial Tmm candidates investigated, eight enzymes from four different taxa were selected for their high activity toward TMA.","claim_type":"general_molecular","extracted_value":"Eight bacterial Tmm enzymes from four different taxa showed high activity toward TMA","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Eight bacterial Tmm enzymes from four different taxa showed high activity toward TMA' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300017","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270003#claim-300017","created_at":"2026-06-10T09:51:03.000Z","updated_at":"2026-06-10T09:51:11.000Z"},{"id":"ptd-270003-300020","claim_id":300020,"document_id":270003,"document_title":"Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates.","vertical_domain":"salmon_biotech","claim_text":"All three Tmms, given sufficient NADPH cofactor, were found to generate TMAO in the TMA-rich salmon protein hydrolysate.","claim_type":"general_molecular","extracted_value":"Three Tmms generate TMAO in TMA-rich salmon protein hydrolysate with NADPH cofactor","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Three Tmms generate TMAO in TMA-rich salmon protein hydrolysate with NADPH cofactor' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300020","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270003#claim-300020","created_at":"2026-06-10T09:51:03.000Z","updated_at":"2026-06-10T09:51:10.000Z"},{"id":"ptd-270003-300018","claim_id":300018,"document_id":270003,"document_title":"Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates.","vertical_domain":"salmon_biotech","claim_text":"The three most active enzymes were shown to vary in temperature optimum, with the highest being 45°C.","claim_type":"general_molecular","extracted_value":"The highest temperature optimum for the three most active enzymes was 45°C","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'The highest temperature optimum for the three most active enzymes was 45°C' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300018","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270003#claim-300018","created_at":"2026-06-10T09:51:03.000Z","updated_at":"2026-06-10T09:51:10.000Z"},{"id":"ptd-270003-300016","claim_id":300016,"document_id":270003,"document_title":"Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates.","vertical_domain":"salmon_biotech","claim_text":"Purified, recombinant enzymes were assessed for their biocatalytic capacity by monitoring NADPH consumption and TMAO generation.","claim_type":"experimental_method","extracted_value":"monitoring NADPH consumption and TMAO generation","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'monitoring NADPH consumption and TMAO generation' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300016","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270003#claim-300016","created_at":"2026-06-10T09:51:03.000Z","updated_at":"2026-06-10T09:51:09.000Z"},{"id":"ptd-270003-300014","claim_id":300014,"document_id":270003,"document_title":"Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates.","vertical_domain":"salmon_biotech","claim_text":"we propose a novel enzymatic strategy to convert TMA into the odorless trimethylamine N-oxide (TMAO) using TMA monooxygenases (Tmms).","claim_type":"general_molecular","extracted_value":"TMA monooxygenases (Tmms) convert TMA into trimethylamine N-oxide (TMAO)","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'TMA monooxygenases (Tmms) convert TMA into trimethylamine N-oxide (TMAO)' not found in PubChem; [adapter] Manual review recommended [Audit note: Ensure the model output includes both the 'Verdict' and 'Rationale' fields as demonstrated in the optimized prompt. The verdict should be one of the specified categories (e.g., 'Insufficient Evidence').]","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300014","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270003#claim-300014","created_at":"2026-06-10T09:51:03.000Z","updated_at":"2026-06-10T09:51:09.000Z"},{"id":"ptd-270003-300015","claim_id":300015,"document_id":270003,"document_title":"Use of Flavin-Containing Monooxygenases for Conversion of Trimethylamine in Salmon Protein Hydrolysates.","vertical_domain":"salmon_biotech","claim_text":"We identified a diverse set of bacterial Tmms using a sequence similarity network.","claim_type":"experimental_method","extracted_value":"sequence similarity network","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'sequence similarity network' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300015","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270003#claim-300015","created_at":"2026-06-10T09:51:03.000Z","updated_at":"2026-06-10T09:51:08.000Z"},{"id":"ptd-270002-300012","claim_id":300012,"document_id":270002,"document_title":"Salmon-Derived Biotech Product Feasibility Analysis","vertical_domain":"salmon_biotech","claim_text":"Secondary product: salmon collagen for nutraceutical, cosmetic, and wound care applications","claim_type":"protein_name","extracted_value":"salmon collagen","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'salmon collagen' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300012","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270002#claim-300012","created_at":"2026-06-10T09:27:09.000Z","updated_at":"2026-06-10T09:27:18.000Z"},{"id":"ptd-270002-300011","claim_id":300011,"document_id":270002,"document_title":"Salmon-Derived Biotech Product Feasibility Analysis","vertical_domain":"salmon_biotech","claim_text":"Global Atlantic salmon production of approximately 3.0 million tonnes generates 1.5 million tonnes of byproducts annually, containing an estimated 180,000–225,000 tonnes of recoverable protein","claim_type":"general_molecular","extracted_value":"180,000–225,000 tonnes of recoverable protein from Atlantic salmon byproducts","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound '180,000–225,000 tonnes of recoverable protein from Atlantic salmon byproducts' not found in PubChem; [adapter] Manual review recommended [Audit note: The prompt should be rephrased to clearly indicate what 'model answer' is expected in this context. If the model is supposed to *generate* the rationale for the 'Insufficient Evidence' verdict, then the provided 'Model answer' is correct. However, if the model is supposed to *critique* the provided 'Rationale' from the optimized prompt, then the current 'Model answer' is incorrect. The current setup makes it seem like the 'Model answer' *is* the rationale from the prompt, which means the model is not performing any task, but rather just echoing the input. Clarify if the 'Model answer' is an example of what *should* be generated or if it's an output to be critiqued. If it's an output to be critiqued, then the model should provide a critique of the given rationale against the validation criteria.]","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300011","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270002#claim-300011","created_at":"2026-06-10T09:27:09.000Z","updated_at":"2026-06-10T09:27:18.000Z"},{"id":"ptd-270002-300008","claim_id":300008,"document_id":270002,"document_title":"Salmon-Derived Biotech Product Feasibility Analysis","vertical_domain":"salmon_biotech","claim_text":"fish are explicitly exempt from transmissible spongiform encephalopathy (TSE) regulations under EU Regulation 722/2012 and FDA guidance because they are not TSE-susceptible species","claim_type":"general_molecular","extracted_value":"fish are not TSE-susceptible species","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'fish are not TSE-susceptible species' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300008","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270002#claim-300008","created_at":"2026-06-10T09:27:09.000Z","updated_at":"2026-06-10T09:27:17.000Z"},{"id":"ptd-270002-300007","claim_id":300007,"document_id":270002,"document_title":"Salmon-Derived Biotech Product Feasibility Analysis","vertical_domain":"salmon_biotech","claim_text":"fish-derived peptones match or exceed the performance of bovine and vegetable alternatives","claim_type":"general_molecular","extracted_value":"fish-derived peptones match or exceed the performance of bovine and vegetable alternatives","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'fish-derived peptones match or exceed the performance of bovine and vegetable alternatives' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300007","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270002#claim-300007","created_at":"2026-06-10T09:27:09.000Z","updated_at":"2026-06-10T09:27:17.000Z"},{"id":"ptd-270002-300010","claim_id":300010,"document_id":270002,"document_title":"Salmon-Derived Biotech Product Feasibility Analysis","vertical_domain":"salmon_biotech","claim_text":"containing superior methionine and leucine profiles plus omega-3 fatty acids absent from all terrestrial sources","claim_type":"general_molecular","extracted_value":"superior methionine and leucine profiles plus omega-3 fatty acids","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'superior methionine and leucine profiles plus omega-3 fatty acids' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300010","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270002#claim-300010","created_at":"2026-06-10T09:27:09.000Z","updated_at":"2026-06-10T09:27:16.000Z"},{"id":"ptd-270002-300009","claim_id":300009,"document_id":270002,"document_title":"Salmon-Derived Biotech Product Feasibility Analysis","vertical_domain":"salmon_biotech","claim_text":"salmon head peptone performs equivalently to commercial animal peptone in recombinant protein production (p > 0.05) and actually outperforms vegetable peptone","claim_type":"general_molecular","extracted_value":"salmon head peptone performs equivalently to commercial animal peptone in recombinant protein production (p > 0.05) and actually outperforms vegetable peptone","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'salmon head peptone performs equivalently to commercial animal peptone in recombinant protein production (p > 0.05) and actually outperforms vegetable peptone' not found in PubChem; [adapter] Manual review recommended [Audit note: The model needs to include the 'Verdict' field in its output, consistent with the optimized prompt's example. The prompt should explicitly state that both 'Verdict' and 'Rationale' are required fields for the output.]","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300009","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270002#claim-300009","created_at":"2026-06-10T09:27:09.000Z","updated_at":"2026-06-10T09:27:15.000Z"},{"id":"ptd-270001-300004","claim_id":300004,"document_id":270001,"document_title":"Salmon-Derived Biotech Product Feasibility Analysis","vertical_domain":"salmon_biotech","claim_text":"containing superior methionine and leucine profiles plus omega-3 fatty acids absent from all terrestrial sources","claim_type":"general_molecular","extracted_value":"salmon head peptone containing superior methionine and leucine profiles plus omega-3 fatty acids","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'salmon head peptone containing superior methionine and leucine profiles plus omega-3 fatty acids' not found in PubChem; [adapter] Manual review recommended [Audit note: The model should be instructed to explicitly output both the 'Verdict' and 'Rationale' sections as provided in the optimized prompt. For example, 'Verdict: Insufficient Evidence. Rationale: Source completeness gate failed...'.]","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300004","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270001#claim-300004","created_at":"2026-06-10T09:26:47.000Z","updated_at":"2026-06-10T09:26:55.000Z"},{"id":"ptd-270001-300003","claim_id":300003,"document_id":270001,"document_title":"Salmon-Derived Biotech Product Feasibility Analysis","vertical_domain":"salmon_biotech","claim_text":"salmon head peptone performs equivalently to commercial animal peptone in recombinant protein production (p > 0.05) and actually outperforms vegetable peptone","claim_type":"general_molecular","extracted_value":"salmon head peptone performs equivalently to commercial animal peptone in recombinant protein production (p > 0.05) and actually outperforms vegetable peptone","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'salmon head peptone performs equivalently to commercial animal peptone in recombinant protein production (p > 0.05) and actually outperforms vegetable peptone' not found in PubChem; [adapter] Manual review recommended [Audit note: The model should be instructed to always provide the 'Verdict' field, as it is a core component of the expected output structure and crucial for satisfying the deep intent of evaluating a claim. The prompt should explicitly state that the output format should match the 'Verdict: [value]\\nRationale: [value]' structure, or ideally, a JSON structure including both fields.]","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300003","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270001#claim-300003","created_at":"2026-06-10T09:26:47.000Z","updated_at":"2026-06-10T09:26:54.000Z"},{"id":"ptd-270001-300006","claim_id":300006,"document_id":270001,"document_title":"Salmon-Derived Biotech Product Feasibility Analysis","vertical_domain":"salmon_biotech","claim_text":"Sequential extraction recovers collagen from skin and bones first, then hydrolyzes residual protein into peptone","claim_type":"general_molecular","extracted_value":"Sequential extraction recovers collagen from skin and bones first, then hydrolyzes residual protein into peptone","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Sequential extraction recovers collagen from skin and bones first, then hydrolyzes residual protein into peptone' not found in PubChem; [adapter] Manual review recommended [Audit note: The model must include the 'Verdict' field as specified in the optimized prompt. For example, it should output: 'Verdict: Insufficient EvidenceRationale: Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Sequential extraction recovers collagen from skin and bones first, then hydrolyzes residual protein into peptone' not found in PubChem; [adapter] Manual review recommended']","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300006","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270001#claim-300006","created_at":"2026-06-10T09:26:47.000Z","updated_at":"2026-06-10T09:26:53.000Z"},{"id":"ptd-270001-300005","claim_id":300005,"document_id":270001,"document_title":"Salmon-Derived Biotech Product Feasibility Analysis","vertical_domain":"salmon_biotech","claim_text":"Global Atlantic salmon production of approximately 3.0 million tonnes generates 1.5 million tonnes of byproducts annually, containing an estimated 180,000–225,000 tonnes of recoverable protein","claim_type":"general_molecular","extracted_value":"Atlantic salmon byproducts contain 180,000–225,000 tonnes of recoverable protein annually","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'Atlantic salmon byproducts contain 180,000–225,000 tonnes of recoverable protein annually' not found in PubChem; [adapter] Manual review recommended [Audit note: The model should be instructed to output both the 'Verdict' and 'Rationale' as separate fields, consistent with the optimized prompt's structure. For example, 'Verdict: Insufficient Evidence. Rationale: [model output]'. The current prompt provides the verdict, so the model should be instructed to include it in its output.]","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300005","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270001#claim-300005","created_at":"2026-06-10T09:26:47.000Z","updated_at":"2026-06-10T09:26:53.000Z"},{"id":"ptd-270001-300001","claim_id":300001,"document_id":270001,"document_title":"Salmon-Derived Biotech Product Feasibility Analysis","vertical_domain":"salmon_biotech","claim_text":"fish-derived peptones match or exceed the performance of bovine and vegetable alternatives","claim_type":"general_molecular","extracted_value":"fish-derived peptones match or exceed the performance of bovine and vegetable alternatives","pdb_id":null,"verdict":"Insufficient Evidence","verdict_rationale":"Source completeness gate failed: Primary source not found; Required field absent in source record; Source data may be stale; [adapter] Compound 'fish-derived peptones match or exceed the performance of bovine and vegetable alternatives' not found in PubChem; [adapter] Manual review recommended","confidence_score":null,"verdict_method":"completeness_gate","evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/300001","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/270001#claim-300001","created_at":"2026-06-10T09:26:47.000Z","updated_at":"2026-06-10T09:26:53.000Z"},{"id":"ptd-60110-121600","claim_id":121600,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"It is also important to acknowledge that cycloviolacins, including cycloviolacin O13, have been reported in the literature as membrane-active peptides with antimicrobial and cytotoxic properties, particularly at higher concentrations50–52.","claim_type":"ligand","extracted_value":"cycloviolacin O13","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.565,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121600","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121600","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121599","claim_id":121599,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"In direct contrast, apo-VEGFR2 showed larger drift and expansion (RMSD 0.30–0.55 nm, excursions to 0.60 nm; Rg rising toward 1.82–1.86 nm; 150–200 H-bonds), supporting a ligand-associated stabilization of the predicted pocket.","claim_type":"general_molecular","extracted_value":"150–200 H-bonds","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121599","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121599","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121598","claim_id":121598,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"In direct contrast, apo-VEGFR2 showed larger drift and expansion (RMSD 0.30–0.55 nm, excursions to 0.60 nm; Rg rising toward 1.82–1.86 nm; 150–200 H-bonds), supporting a ligand-associated stabilization of the predicted pocket.","claim_type":"general_molecular","extracted_value":"Rg rising toward 1.82–1.86 nm","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121598","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121598","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121597","claim_id":121597,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"In direct contrast, apo-VEGFR2 showed larger drift and expansion (RMSD 0.30–0.55 nm, excursions to 0.60 nm; Rg rising toward 1.82–1.86 nm; 150–200 H-bonds), supporting a ligand-associated stabilization of the predicted pocket.","claim_type":"general_molecular","extracted_value":"RMSD 0.30–0.55 nm","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121597","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121597","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121596","claim_id":121596,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"In direct contrast, apo-VEGFR2 showed larger drift and expansion (RMSD 0.30–0.55 nm, excursions to 0.60 nm; Rg rising toward 1.82–1.86 nm; 150–200 H-bonds), supporting a ligand-associated stabilization of the predicted pocket.","claim_type":"protein_name","extracted_value":"VEGFR2","pdb_id":null,"verdict":"Ambiguous","verdict_rationale":"Protein name \"VEGFR2\" matches 3 PDB entries (e.g. 7YPL, 7LSB, 7LSI). Specific PDB ID required for definitive verification.","confidence_score":0.745,"verdict_method":null,"evidence_url":"https://www.rcsb.org/search?query=VEGFR2","page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121596","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121596","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121595","claim_id":121595,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"In our computational pipeline, cycloviolacin O13 emerged as the lead cyclotide because it combined the strongest docking performance (HADDOCK score − 84.7, ligand RMSD 0.8 nm) with long-timescale complex persistence during 500 ns MD: complex RMSD stabilized at 0.25–0.45 nm, the binding pose remained tight (ligand RMSD 0.20–0.30 nm), the complex compacted (Rg drifting from 1.83 to 1.88 nm early to 1.72–1.76 nm after ~ 150 ns), and hydrogen-bonding remained sustained (200–260 H-bonds).","claim_type":"general_molecular","extracted_value":"200–260 H-bonds","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121595","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121595","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121594","claim_id":121594,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"In our computational pipeline, cycloviolacin O13 emerged as the lead cyclotide because it combined the strongest docking performance (HADDOCK score − 84.7, ligand RMSD 0.8 nm) with long-timescale complex persistence during 500 ns MD: complex RMSD stabilized at 0.25–0.45 nm, the binding pose remained tight (ligand RMSD 0.20–0.30 nm), the complex compacted (Rg drifting from 1.83 to 1.88 nm early to 1.72–1.76 nm after ~ 150 ns), and hydrogen-bonding remained sustained (200–260 H-bonds).","claim_type":"general_molecular","extracted_value":"Rg drifting from 1.83 to 1.88 nm early to 1.72–1.76 nm after ~ 150 ns","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121594","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121594","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121593","claim_id":121593,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"In our computational pipeline, cycloviolacin O13 emerged as the lead cyclotide because it combined the strongest docking performance (HADDOCK score − 84.7, ligand RMSD 0.8 nm) with long-timescale complex persistence during 500 ns MD: complex RMSD stabilized at 0.25–0.45 nm, the binding pose remained tight (ligand RMSD 0.20–0.30 nm), the complex compacted (Rg drifting from 1.83 to 1.88 nm early to 1.72–1.76 nm after ~ 150 ns), and hydrogen-bonding remained sustained (200–260 H-bonds).","claim_type":"general_molecular","extracted_value":"ligand RMSD 0.20–0.30 nm","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121593","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121593","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121592","claim_id":121592,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"In our computational pipeline, cycloviolacin O13 emerged as the lead cyclotide because it combined the strongest docking performance (HADDOCK score − 84.7, ligand RMSD 0.8 nm) with long-timescale complex persistence during 500 ns MD: complex RMSD stabilized at 0.25–0.45 nm, the binding pose remained tight (ligand RMSD 0.20–0.30 nm), the complex compacted (Rg drifting from 1.83 to 1.88 nm early to 1.72–1.76 nm after ~ 150 ns), and hydrogen-bonding remained sustained (200–260 H-bonds).","claim_type":"general_molecular","extracted_value":"complex RMSD stabilized at 0.25–0.45 nm","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121592","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121592","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121591","claim_id":121591,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"In our computational pipeline, cycloviolacin O13 emerged as the lead cyclotide because it combined the strongest docking performance (HADDOCK score − 84.7, ligand RMSD 0.8 nm) with long-timescale complex persistence during 500 ns MD: complex RMSD stabilized at 0.25–0.45 nm, the binding pose remained tight (ligand RMSD 0.20–0.30 nm), the complex compacted (Rg drifting from 1.83 to 1.88 nm early to 1.72–1.76 nm after ~ 150 ns), and hydrogen-bonding remained sustained (200–260 H-bonds).","claim_type":"experimental_method","extracted_value":"MD simulations over 500 ns","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.605,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121591","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121591","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121590","claim_id":121590,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"In our computational pipeline, cycloviolacin O13 emerged as the lead cyclotide because it combined the strongest docking performance (HADDOCK score − 84.7, ligand RMSD 0.8 nm) with long-timescale complex persistence during 500 ns MD: complex RMSD stabilized at 0.25–0.45 nm, the binding pose remained tight (ligand RMSD 0.20–0.30 nm), the complex compacted (Rg drifting from 1.83 to 1.88 nm early to 1.72–1.76 nm after ~ 150 ns), and hydrogen-bonding remained sustained (200–260 H-bonds).","claim_type":"general_molecular","extracted_value":"ligand RMSD 0.8 nm","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121590","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121590","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121589","claim_id":121589,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"In our computational pipeline, cycloviolacin O13 emerged as the lead cyclotide because it combined the strongest docking performance (HADDOCK score − 84.7, ligand RMSD 0.8 nm) with long-timescale complex persistence during 500 ns MD: complex RMSD stabilized at 0.25–0.45 nm, the binding pose remained tight (ligand RMSD 0.20–0.30 nm), the complex compacted (Rg drifting from 1.83 to 1.88 nm early to 1.72–1.76 nm after ~ 150 ns), and hydrogen-bonding remained sustained (200–260 H-bonds).","claim_type":"general_molecular","extracted_value":"HADDOCK score of -84.7","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121589","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121589","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121588","claim_id":121588,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"In our computational pipeline, cycloviolacin O13 emerged as the lead cyclotide because it combined the strongest docking performance (HADDOCK score − 84.7, ligand RMSD 0.8 nm) with long-timescale complex persistence during 500 ns MD: complex RMSD stabilized at 0.25–0.45 nm, the binding pose remained tight (ligand RMSD 0.20–0.30 nm), the complex compacted (Rg drifting from 1.83 to 1.88 nm early to 1.72–1.76 nm after ~ 150 ns), and hydrogen-bonding remained sustained (200–260 H-bonds).","claim_type":"ligand","extracted_value":"cycloviolacin O13","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.585,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121588","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121588","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121587","claim_id":121587,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"The results of a comparative MD analysis based on the geometry of the VEGFR2-cycloviolacinO13 complex, apo VEGFR2 as well as the free peptide showed that cycloviolacinO13 pro-stabilizes the receptor and is computationally prioritized for its biological activity relevant to wound-site angiogenesis.","claim_type":"ligand","extracted_value":"cycloviolacinO13","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.565,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121587","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121587","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121586","claim_id":121586,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"The results of a comparative MD analysis based on the geometry of the VEGFR2-cycloviolacinO13 complex, apo VEGFR2 as well as the free peptide showed that cycloviolacinO13 pro-stabilizes the receptor and is computationally prioritized for its biological activity relevant to wound-site angiogenesis.","claim_type":"protein_name","extracted_value":"VEGFR2","pdb_id":null,"verdict":"Ambiguous","verdict_rationale":"Protein name \"VEGFR2\" matches 3 PDB entries (e.g. 7YPL, 7LSB, 7LSI). Specific PDB ID required for definitive verification.","confidence_score":0.725,"verdict_method":null,"evidence_url":"https://www.rcsb.org/search?query=VEGFR2","page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121586","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121586","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121585","claim_id":121585,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"The results of a comparative MD analysis based on the geometry of the VEGFR2-cycloviolacinO13 complex, apo VEGFR2 as well as the free peptide showed that cycloviolacinO13 pro-stabilizes the receptor and is computationally prioritized for its biological activity relevant to wound-site angiogenesis.","claim_type":"experimental_method","extracted_value":"comparative MD analysis","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.605,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121585","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121585","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121584","claim_id":121584,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"Only 0.4% of residues were observed in generously allowed regions and 0.4% in disallowed regions.","claim_type":"general_molecular","extracted_value":"0.4% of residues in disallowed regions","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. 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Specific PDB ID required for definitive verification.","confidence_score":0.725,"verdict_method":null,"evidence_url":"https://www.rcsb.org/search?query=VEGFR2","page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121564","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121564","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121563","claim_id":121563,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"The structure used in this study was PDB ID: 3V2A, an X-ray crystallographic structure of the VEGFR2 extracellular ligand-binding region in complex with VEGF-A, determined at a resolution of 3.20 A.","claim_type":"experimental_method","extracted_value":"X-ray crystallography","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. 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Specific PDB ID required for definitive verification.","confidence_score":0.695,"verdict_method":null,"evidence_url":"https://www.rcsb.org/search?query=VEGFR2","page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121561","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121561","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121560","claim_id":121560,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"These results identify cycloviolacin O13 as a structurally stable and immunologically low-risk lead that can form a persistent, dynamically stable complex with VEGFR2 at a predicted binding pocket.","claim_type":"protein_name","extracted_value":"VEGFR2","pdb_id":null,"verdict":"Ambiguous","verdict_rationale":"Protein name \"VEGFR2\" matches 3 PDB entries (e.g. 7YPL, 7LSB, 7LSI). Specific PDB ID required for definitive verification.","confidence_score":0.725,"verdict_method":null,"evidence_url":"https://www.rcsb.org/search?query=VEGFR2","page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121560","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121560","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121559","claim_id":121559,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"These results identify cycloviolacin O13 as a structurally stable and immunologically low-risk lead that can form a persistent, dynamically stable complex with VEGFR2 at a predicted binding pocket.","claim_type":"ligand","extracted_value":"cycloviolacin O13","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.565,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121559","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121559","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121558","claim_id":121558,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"Immuno-informatics evaluations found that cycloviolacin O13 was non-antigenic, non-allergenic and nontoxic, with immune simulations showing no adverse B- or T-cell response.","claim_type":"ligand","extracted_value":"cycloviolacin O13","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.565,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121558","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121558","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121557","claim_id":121557,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"Dynamic cross-corr and principal component analyses supported the coordinated motions and a stable conformational response to peptide binding, and normal mode analysis suggested that low deformation and high mechanical resilience occur.","claim_type":"experimental_method","extracted_value":"normal mode analysis","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.605,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121557","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121557","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121556","claim_id":121556,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"Dynamic cross-corr and principal component analyses supported the coordinated motions and a stable conformational response to peptide binding, and normal mode analysis suggested that low deformation and high mechanical resilience occur.","claim_type":"experimental_method","extracted_value":"principal component analysis","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.605,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121556","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121556","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121555","claim_id":121555,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"Dynamic cross-corr and principal component analyses supported the coordinated motions and a stable conformational response to peptide binding, and normal mode analysis suggested that low deformation and high mechanical resilience occur.","claim_type":"experimental_method","extracted_value":"Dynamic cross-corr analysis","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.605,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121555","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121555","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121554","claim_id":121554,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"Molecular dynamics simulations over a period of 500 nanoseconds (ns) verified the stability of the VEGFR2-O13 complex in which root mean square deviation (RMSD) values were stabilized at 0.25–0.45 nm, compact radius of gyration and a permanent hydrogen bond network involving 200 to 260 hydrogen bonds.","claim_type":"general_molecular","extracted_value":"200 to 260 hydrogen bonds","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121554","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121554","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121553","claim_id":121553,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"Molecular dynamics simulations over a period of 500 nanoseconds (ns) verified the stability of the VEGFR2-O13 complex in which root mean square deviation (RMSD) values were stabilized at 0.25–0.45 nm, compact radius of gyration and a permanent hydrogen bond network involving 200 to 260 hydrogen bonds.","claim_type":"general_molecular","extracted_value":"RMSD values were stabilized at 0.25–0.45 nm","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121553","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121553","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121552","claim_id":121552,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"Molecular dynamics simulations over a period of 500 nanoseconds (ns) verified the stability of the VEGFR2-O13 complex in which root mean square deviation (RMSD) values were stabilized at 0.25–0.45 nm, compact radius of gyration and a permanent hydrogen bond network involving 200 to 260 hydrogen bonds.","claim_type":"ligand","extracted_value":"O13","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.585,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121552","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121552","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121551","claim_id":121551,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"Molecular dynamics simulations over a period of 500 nanoseconds (ns) verified the stability of the VEGFR2-O13 complex in which root mean square deviation (RMSD) values were stabilized at 0.25–0.45 nm, compact radius of gyration and a permanent hydrogen bond network involving 200 to 260 hydrogen bonds.","claim_type":"protein_name","extracted_value":"VEGFR2","pdb_id":null,"verdict":"Ambiguous","verdict_rationale":"Protein name \"VEGFR2\" matches 3 PDB entries (e.g. 7YPL, 7LSB, 7LSI). Specific PDB ID required for definitive verification.","confidence_score":0.745,"verdict_method":null,"evidence_url":"https://www.rcsb.org/search?query=VEGFR2","page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121551","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121551","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121550","claim_id":121550,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"Molecular dynamics simulations over a period of 500 nanoseconds (ns) verified the stability of the VEGFR2-O13 complex in which root mean square deviation (RMSD) values were stabilized at 0.25–0.45 nm, compact radius of gyration and a permanent hydrogen bond network involving 200 to 260 hydrogen bonds.","claim_type":"experimental_method","extracted_value":"Molecular dynamics simulations","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.605,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121550","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121550","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121549","claim_id":121549,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"A curated library of twenty-five cyclotides was modelled using AlphaFold, of which cycloviolacin O13 showed the best interaction with VEGFR2 as judged by a HADDOCK score of -84.7 and a ligand root-mean-squared deviation of 0.8 nm.","claim_type":"general_molecular","extracted_value":"ligand root-mean-squared deviation of 0.8 nm","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121549","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121549","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121548","claim_id":121548,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"A curated library of twenty-five cyclotides was modelled using AlphaFold, of which cycloviolacin O13 showed the best interaction with VEGFR2 as judged by a HADDOCK score of -84.7 and a ligand root-mean-squared deviation of 0.8 nm.","claim_type":"general_molecular","extracted_value":"HADDOCK score of -84.7","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121548","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121548","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121547","claim_id":121547,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"A curated library of twenty-five cyclotides was modelled using AlphaFold, of which cycloviolacin O13 showed the best interaction with VEGFR2 as judged by a HADDOCK score of -84.7 and a ligand root-mean-squared deviation of 0.8 nm.","claim_type":"protein_name","extracted_value":"VEGFR2","pdb_id":null,"verdict":"Ambiguous","verdict_rationale":"Protein name \"VEGFR2\" matches 3 PDB entries (e.g. 7YPL, 7LSB, 7LSI). Specific PDB ID required for definitive verification.","confidence_score":0.745,"verdict_method":null,"evidence_url":"https://www.rcsb.org/search?query=VEGFR2","page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121547","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121547","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121546","claim_id":121546,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"A curated library of twenty-five cyclotides was modelled using AlphaFold, of which cycloviolacin O13 showed the best interaction with VEGFR2 as judged by a HADDOCK score of -84.7 and a ligand root-mean-squared deviation of 0.8 nm.","claim_type":"ligand","extracted_value":"cycloviolacin O13","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.585,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121546","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121546","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121545","claim_id":121545,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"A curated library of twenty-five cyclotides was modelled using AlphaFold, of which cycloviolacin O13 showed the best interaction with VEGFR2 as judged by a HADDOCK score of -84.7 and a ligand root-mean-squared deviation of 0.8 nm.","claim_type":"experimental_method","extracted_value":"AlphaFold","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.605,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121545","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121545","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"},{"id":"ptd-60110-121544","claim_id":121544,"document_id":60110,"document_title":"Computational screening of AI-derived cyclotides as putative VEGFR2 binders for wound-site angiogenesis.","vertical_domain":"structural_biology","claim_text":"The receptor structure was obtained from Protein Data Bank and the structure was checked using ERRAT (81.176) along with Ramachandran analysis which resulted in 79.8% favored residues.","claim_type":"general_molecular","extracted_value":"79.8% favored residues","pdb_id":null,"verdict":"Out of Scope","verdict_rationale":"This claim type cannot be automatically verified against the Protein Data Bank. Expert review recommended.","confidence_score":0.545,"verdict_method":null,"evidence_url":null,"page_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/claim/121544","audit_url":"https://b2mbh3cn4a-w6dvs6ghja-uk.a.run.app/audit/60110#claim-121544","created_at":"2026-06-03T10:10:36.000Z","updated_at":"2026-06-09T06:02:29.000Z"}]}